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The 2009 Nobel Prize in physiology1 or medicine goes to Harvard’s Jack2 Szostak, Johns Hopkins’s Carol Greider and Elizabeth Blackburn at U.C. San Francisco for their work on how chromosomes3 are protected by telomeres and the enzyme4 telomerase.
The Nobel laureates’ research helped explain how an organism’s DNA5 is successfully copied when cells divide. Telomeres are genetic6 sequences that act like little protective caps at the end of chromosomes—think of the sealed tips of your shoelaces. Telomerase is the enzyme that builds telomeres.
Blackburn and Szostak determined7 that it was a specific DNA sequence in the telomeres that kept chromosomes from fraying8 whenever they were copied when a cell splits in two. Blackburn and Greider discovered telomerase. The findings have implications for the understanding of aging and cancer. Because if the enzyme keeps the telomeres robust9, the chromosomes stay protected and the cell’s aging is slowed. And in cancer cells, which unfortunately do not seem to age, telomere length is maintained virtually indefinitely. Szostak, Greider and Blackburn thus revealed one of life’s basic mechanisms10, and paved the way for new medical strategies.
1 physiology | |
n.生理学,生理机能 | |
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2 jack | |
n.插座,千斤顶,男人;v.抬起,提醒,扛举;n.(Jake)杰克 | |
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3 chromosomes | |
n.染色体( chromosome的名词复数 ) | |
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4 enzyme | |
n.酵素,酶 | |
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5 DNA | |
(缩)deoxyribonucleic acid 脱氧核糖核酸 | |
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6 genetic | |
adj.遗传的,遗传学的 | |
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7 determined | |
adj.坚定的;有决心的 | |
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8 fraying | |
v.(使布、绳等)磨损,磨破( fray的现在分词 ) | |
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9 robust | |
adj.强壮的,强健的,粗野的,需要体力的,浓的 | |
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10 mechanisms | |
n.机械( mechanism的名词复数 );机械装置;[生物学] 机制;机械作用 | |
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