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科学美国人60秒 SSS Ebola Virus Grew More Infectious in the Latest Epidemic

时间:2017-03-06 05:22来源:互联网 提供网友:nan   字体: [ ]
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    (单词翻译:双击或拖选)

 

Ebola outbreaks before the most recent one have been fairly contained: geographically1 limited, and just a couple hundred cases. The latest outbreak, though, which started in late 2013 and lasted more than two years, was entirely2 different. “There were almost 30,000 cases.” Jeremy Luban, a virologist at the University of Massachusetts Medical School. “You could argue this was the first actual epidemic3.”

Luban and his colleagues studied publicly available data on the evolutionary4 “family tree” of the Ebola virus during the latest outbreak—how the strains mutated and changed over time. “And one in particular caught our attention. It arose early in the epidemic, and it’s the only form of the virus that persisted beyond that point.” 

This mutant strain was armed with an alteration5 in the protein it uses to enter cells. What Luban’s team found was that the modified protein actually made the strain more infectious to the cells of humans and other primates—but not to other mammals. The study is in the journal Cell. [William E. Diehl et al., Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic]

Luban says it’s unclear whether this increased infectivity helped drive the outbreak to epidemic proportions. Or whether the length and size of the epidemic simply allowed for more virulent6 strains like this one to appear. Still, he says, studying these strains helps us understand how the virus infects—and replicates7. “That may help us treat infections in the future, to develop therapies, or to develop vaccines8 to block an infection.” In other words: know thy enemy. 

—Christopher Intagliata


点击收听单词发音收听单词发音  

1 geographically mg6xa     
adv.地理学上,在地理上,地理方面
参考例句:
  • Geographically, the UK is on the periphery of Europe. 从地理位置上讲,英国处于欧洲边缘。 来自辞典例句
  • All these events, however geographically remote, urgently affected Western financial centers. 所有这些事件,无论发生在地理上如何遥远的地方,都对西方金融中心产生紧迫的影响。 来自名作英译部分
2 entirely entirely     
ad.全部地,完整地;完全地,彻底地
参考例句:
  • The fire was entirely caused by their neglect of duty. 那场火灾完全是由于他们失职而引起的。
  • His life was entirely given up to the educational work. 他的一生统统献给了教育工作。
3 epidemic 5iTzz     
n.流行病;盛行;adj.流行性的,流传极广的
参考例句:
  • That kind of epidemic disease has long been stamped out.那种传染病早已绝迹。
  • The authorities tried to localise the epidemic.当局试图把流行病限制在局部范围。
4 evolutionary Ctqz7m     
adj.进化的;演化的,演变的;[生]进化论的
参考例句:
  • Life has its own evolutionary process.生命有其自身的进化过程。
  • These are fascinating questions to be resolved by the evolutionary studies of plants.这些十分吸引人的问题将在研究植物进化过程中得以解决。
5 alteration rxPzO     
n.变更,改变;蚀变
参考例句:
  • The shirt needs alteration.这件衬衣需要改一改。
  • He easily perceived there was an alteration in my countenance.他立刻看出我的脸色和往常有些不同。
6 virulent 1HtyK     
adj.有毒的,有恶意的,充满敌意的
参考例句:
  • She is very virulent about her former employer.她对她过去的老板恨之入骨。
  • I stood up for her despite the virulent criticism.尽管她遭到恶毒的批评,我还是维护她。
7 replicates 2cb25c60b573b908924058afde2ecd5a     
复制( replicate的第三人称单数 ); 重复; 再造; 再生
参考例句:
  • The bluetongue virus replicates in the insect. 蓝舌病病毒在这种昆虫体内繁殖。
  • The chameleon's skin replicates the pattern of its surroundings. 变色龙的皮肤可随环境的模式而改变颜色。
8 vaccines c9bb57973a82c1e95c7cd0f4988a1ded     
疫苗,痘苗( vaccine的名词复数 )
参考例句:
  • His team are at the forefront of scientific research into vaccines. 他的小组处于疫苗科研的最前沿。
  • The vaccines were kept cool in refrigerators. 疫苗放在冰箱中冷藏。
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