美国科学60秒 SSS 2015-05-29(在线收听

 Some 70 million American adults have high blood pressure. Three quarters of them rely on medication to keep the condition in check. But you've got to remember to actually take the daily dose. Now researchers have devised a longer-lasting alternative: a vaccine to lower blood pressure...for rats, at least. 

 
Scientists jabbed hypertensive rates with three doses of the formulation. It's a DNA vaccine, containing DNA fragments from angiotensin II—a hormone that boosts blood pressure as well as fragments from hepatitis B, to guarantee the immune system's attention. Cells suck up the vaccine's DNA and start pumping out the proteins the DNA codes for. When the host's defenses get a whiff (a smell that is only smelled briefly or faintly) from the proteins, it reacts. It really revs up (make or become active or energetic) against the hepatitis B fragments, and while it's at it, it starts taking out some angiotensin II as well. 
 
The result is a reduction of angiotensin II's usual blood raising effect, similar to what blood pressure meds like Benicar do. Less angiotensin II means more relaxed blood vessels and a drop in pressure. That effect lasted six months in the vaccinated rats, and lengthened their lifespan by eight weeks. Necropsies on the vaccinated rats revealed healthier heart tissue than normally found with high blood pressure, and no damage to the kidneys or livers. The results are in the journey Hypertension. 
 
Other blood pressure vaccines have been tried, unsuccessfully, but this naval DNA-based vaccine could induce (bring about or give rise to) longer-lasting effect, and the hope of twice yearly shot instead of daily pills. 
 
  原文地址:http://www.tingroom.com/lesson/sasss/2015/5/309878.html