We would like to begin with that. 我们先从那个开始吧。

　　Let me begin by saying that a terrible tragedy has occurred here. 我先告诉您，这里发生了一场惨剧。

　　I want to be successful at my job.  我想在事业上大有所成。

　　That begins with a lot of hard work.  那要从努力工作开始了。