纪录片《狗狗秘闻》 34从狗身上找出疾病的原因（在线收听）

Dr Karlsson is part of

卡森教授是2005年狗基因组

the team that in 2005 mapped the dog genome,

绘制团队的成员

All 2.4 billion letters of the dog's DNA code.

这种狗的DNA码　有24亿个字母

Once we had the dog genome sequence,

一旦我们知道了基因组序列

we could design a gene chip, which would allow us to compare

我们就可以设计基因芯片　让我们可以

all of our sick dogs and our healthy dogs

把那些生病的狗和健康的狗做比较

and find the genes that are causing diseases.

找到那些引起疾病的基因

Using a genotyping machine, Dr. Karlsson

利用基因分型设备　卡森博士

is able to simultaneously analyse thousands of regions of DNA

可以同时分析取自生病的 和健康的拳师狗

From boxers with and without cardiomyopathy.

的数千个区域的DNA

What you see when you compare sick dogs to healthy dogs

把生病的狗和健康的狗相比较

and go across the genome from chromosome one

从染色体一比较

to chromosome two and across is that most of the points

到染色体二 看到大多数的点

are right near zero and there's not a lot

都很接近零 就是说在病狗和健康狗之间

of differences between the healthy dogs and the sick dogs,

这些基因没有明显的不同

Until you get to chromosome 17, and there

直到我们看到染色体17的地方

all of a sudden you have a huge number of differences.

这里的数据突然出现了很大的差别

This is exciting, because this means

这很让人兴奋　因为这意味着

this is the region of the

正是基因组的这个区域

genome that holds the gene causing our disease.

含有引起疾病的基因

Karlsson's team have honed

卡森的团队锁定这个区域

in on this region to pinpoint the exact gene.

精确的找到了致病基因

We've found a gene related to sudden cardiac death.

我们发现了一种与心脏病猝死有关的基因

We think there's another one

我们认为还会有另外一个基因

because we haven't told the whole story yet.

因为我们还不能完全解释病症是如何发生的

But we think we know what the

但是我们相信

mutation is in that gene causing the disease.

那个基因的突变导致了这类疾病

Now the mutation has been identified,

现在突变的基因找到了

the team have been able

这个团队可以着手

to locate the corresponding gene in humans.

在人类身上定位类似的基因

It's accelerated a process that,

这样就加速了整个过程

without dogs, could have taken decades.

而如果没有狗狗　这可能要花费数十年时间