研究人员利用脑细胞延缓老鼠衰老

Researchers Use Brain Cells to Control Aging in Mice

It is a question people have been asking for—well-- ages. Is there a way to turn back the aging process in people?

For centuries, people have been looking for a “fountain of youth.” The idea is that if you find a magical fountain, and drink from its waters, you will not age.

Spanish explorer Juan Ponce de León searched for waters with magical powers in the early 1500s. But what he found instead is the American state of Florida.

Researchers in New York did not find an actual fountain of youth, but they may have found a way to turn back the aging process. It appears the answer may be hidden right between your eyes, in an area called the hypothalamus.

The hypothalamus is part of your brain. It controls important activities within the body. They include growth, reproduction and the way we process food.

Researchers at New York’s Albert Einstein College of Medicine found that hypothalamus neural¹ stem cells also influence how fast aging takes place in the body.

What are stem cells? They are simple cells that can develop into specialized² cells, like blood or skin cells. Stem cells can also repair damaged tissues and organs.

Dongsheng Cai is a professor at the Albert Einstein College of Medicine. He was the lead researcher in a study on aging in mice. He and his team reported their findings in the journal Nature.

Cai explains what they found.

"Aging speed is controlled, can be controlled by a particular place in the body, which is the hypothalamus. And it can be controlled by a particular type of cells, which are hypothalamus stem cells. I think these findings are quite interesting, potentially even remarkable⁴."

He adds that when the hypothalamus starts aging, so does the body.

"So when hypothalamus function is in decline, particularly the loss of hypothalamus stem cells, and this protection against the aging development is lost, it eventually leads to aging."

Using this information, the researchers began trying to activate⁵, or energize⁶, the hypothalamus in laboratory mice. They did this by injecting the animals with stem cells.

Later, the researchers examined tissues and tested for changes in behavior. They looked for changes in the strength and coordination⁷ of the animals’ muscles. They also studied the social behavior and cognitive⁸ ability of the mice.

The researchers say the results show that the treatment slowed aging in the animals.

Cai says injecting middle-aged³ mice with stem cells from younger mice helped the older animals live longer.

"When we injected the hypothalamus stem cells, which were derived¹⁰ from young mice, we injected them to the middle-aged⁹ mice and that was, in fact, to slow down aging. So the mouse aged slowly and they also have increased their lifespan, which is longevity¹¹."

But these results were just from studying mice in a laboratory. If the mice can live longer, does that mean people could have longer lives? The next step is to see if the anti-aging effects also work in human beings.

"If we can translate what we have seen in animals to humans, I think humans, they can function better during later ages, later stage of aging."

Cai and his team say their studies may have other benefits. They say the findings could lead to new ways to help doctors identify and treat any number of age-related health issues.

I’m Anne Ball.

Words in This Story

fountain – n. a device or structure that sends a stream of water into the air in a garden, park, etc

neural – adj. of, relating to, or involving a nerve or the nervous system

remarkable – adj. unusual or surprising : likely to be noticed

function – n. the job or duty of a person

coordination – n. the process of organizing people or groups so that they work together properly and well

cognitive – adj. of, relating to, or involving conscious mental activities (such as thinking, understanding, learning, and remembering)

benefit – n. a good or helpful result or effect

1 neural   

adj.神经的，神经系统的

参考例句：

• The neural network can preferably solve the non- linear problem.利用神经网络建模可以较好地解决非线性问题。
• The information transmission in neural system depends on neurotransmitters.信息传递的神经途径有赖于神经递质。

2 specialized   

adj.专门的，专业化的

参考例句：

• There are many specialized agencies in the United Nations.联合国有许多专门机构。
• These tools are very specialized.这些是专用工具。

3 aged   

adj.年老的，陈年的

参考例句：

• He had put on weight and aged a little.他胖了，也老点了。
• He is aged,but his memory is still good.他已年老，然而记忆力还好。

4 remarkable   

adj.显著的，异常的，非凡的，值得注意的

参考例句：

• She has made remarkable headway in her writing skills.她在写作技巧方面有了长足进步。
• These cars are remarkable for the quietness of their engines.这些汽车因发动机没有噪音而不同凡响。

5 activate   

vt.使活动起来，使开始起作用

参考例句：

• We must activate the youth to study.我们要激励青年去学习。
• These push buttons can activate the elevator.这些按钮能启动电梯。

6 energize   

vt.给予(某人或某物)精力、能量

参考例句：

• It is used to energize the city.它的作用是为城市供给能量。
• This is a great way to energize yourself and give yourself more power!这种方法非常棒，可以激活你的能量，让你有更多的活力！

7 coordination   

n.协调，协作

参考例句：

• Gymnastics is a sport that requires a considerable level of coordination.体操是一项需要高协调性的运动。
• The perfect coordination of the dancers and singers added a rhythmic charm to the performance.舞蹈演员和歌手们配合得很好，使演出更具魅力。

8 cognitive   

adj.认知的，认识的，有感知的

参考例句：

• As children grow older,their cognitive processes become sharper.孩子们越长越大，他们的认知过程变得更为敏锐。
• The cognitive psychologist is like the tinker who wants to know how a clock works.认知心理学者倒很像一个需要通晓钟表如何运转的钟表修理匠。

9 middle-aged   

adj.中年的

参考例句：

• I noticed two middle-aged passengers.我注意到两个中年乘客。
• The new skin balm was welcome by middle-aged women.这种新护肤香膏受到了中年妇女的欢迎。

10 derived   

vi.起源；由来；衍生；导出v.得到( derive的过去式和过去分词 )；（从…中）得到获得；源于；（从…中）提取

参考例句：

• Many English words are derived from Latin and Greek. 英语很多词源出于拉丁文和希腊文。 来自《简明英汉词典》
• He derived his enthusiasm for literature from his father. 他对文学的爱好是受他父亲的影响。 来自《简明英汉词典》

11 longevity   

n.长命；长寿

参考例句：

• Good habits promote longevity.良好的习惯能增长寿命。
• Human longevity runs in families.人类的长寿具有家族遗传性。