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(单词翻译:双击或拖选)
The World Health Organization says studies in Senegal and Mali show it is possible to eliminate river blindness. More than 37 million people are infected with the parasite1 that causes river blindness. While the disease is endemic in some parts of the Americas, 99 percent of those infected are in Africa.
Logo of the World Health Organization at WHO headquarters in Geneva
Onchocerciasis, or river blindness, is transmitted by the black fly, which breeds in rivers. It is a major cause of blindness and also causes debilitating2 skin disease. The disease flourishes in poor, rural communities in west and central Africa.
River Blindness has been treated with a drug called Ivermectin for more than 20 years. The drug, which has been provided free of charge by Merck & Co., successfully stops further infections and transmission of this parasitic3 disease.
But the World Health Organization notes Ivermectin only kills the larvae4, not the adult worms, which cause the disease. Therefore, it says annual or biannual5 treatments must be given to people living in vulnerable African communities to keep the disease in check.
Results of a two-year study in Senegal and Mali show it is possible to stop Ivermectin after many years of treatment without provoking further infections and transmission. Dr. Hans Remme is overall coordinator6 of the study, which was carried out by WHO and numerous partners.
"We actually tested this hypothesis that you could eliminate the parasite and transmission and safely stop treatment," Dr. Remme said. "And, we tested it by actually stopping treatment in five to eight villages in each of the study areas. And, then we followed the population up very intensely for two years. And, the very good news, which is published in this article is that over those two years, we did not find any infected people in those test areas and we did not find any infected black flies and a lot of them were analyzed7. Over 150,000 flies were analyzed annually8. So this is based on very large data."
Dr. Remme calls the study a milestone9. He says further studies are needed to determine to what extent these findings can be extrapolated to other areas in Africa. But, he says, the principle of onchocerciasis elimination10 with Ivermectin treatment has been established.
"It is the first time then that we now can say, "Yes." It takes a long time, but ultimately you can anticipate elimination of Onchocerciasis, not only as a public health problem, but of the parasite and transmission and therefore we can safely stop treatment," Dr. Remme said.
Dr. Remme says researchers are trying to develop a better drug, which would kill or completely sterilize11 the adult worm. Such a drug, he says could eliminate river blindness within six, rather than 15 years.
He says a very promising12 drug, called Moxydectin and manufactured by Wyatt, is currently undergoing trials in the Democratic Republic of Congo, Liberia and Ghana. He says results of these trials should be known by 2012.
1 parasite | |
n.寄生虫;寄生菌;食客 | |
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2 debilitating | |
a.使衰弱的 | |
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3 parasitic | |
adj.寄生的 | |
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4 larvae | |
n.幼虫 | |
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5 biannual | |
adj.一年两次的 | |
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6 coordinator | |
n.协调人 | |
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7 analyzed | |
v.分析( analyze的过去式和过去分词 );分解;解释;对…进行心理分析 | |
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8 annually | |
adv.一年一次,每年 | |
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9 milestone | |
n.里程碑;划时代的事件 | |
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10 elimination | |
n.排除,消除,消灭 | |
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11 sterilize | |
vt.使不结果实;使绝育;使无效;杀菌,消毒 | |
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12 promising | |
adj.有希望的,有前途的 | |
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