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A new study of a popular dietary supplement indicates that, while pine bark extract is safe, it has no significant effect on blood pressure or other risk factors for heart disease. This new research seems to contradict evidence from earlier studies.
Previous research has shown an array of benefits from taking pine bark extract, ranging from reducing inflammation to treating skin disorders1 and menstrual symptoms. It is reported to have antioxidant properties and to help lower blood pressure, as well.
To test out some of the claims, Stanford University researcher Randall Stafford and colleagues recruited people who were overweight and had blood pressure slightly higher than normal — in other words, people likely to try a dietary supplement rather than expensive prescription2 drugs.
People in the study were randomly4 assigned to either take pine bark extract or a look-alike placebo5.
After 12 weeks, the researchers found essentially6 no benefit from the supplement.
"We in fact found no difference between the pine bark extract group and the placebo group," said Stafford. "There were very small changes in blood pressure. And in fact, there was a slightly greater reduction in blood pressure among the placebo group, but it was a change that could have easily been explained by random3 chance."
Stafford says the results were surprising, because previous studies had shown some cardiovascular benefit. But he noted7 that there were problems with the methodology in the earlier studies, which were not placebo-controlled, double-blind trials like his was.
Also, products sold as "pine bark extract" can be made in a variety of ways and are not all the same, since these sorts of nutritional8 supplements are only loosely regulated, at least here in the U.S.
"There are a number of different pine bark extracts out on the market. They are extracted or derived9 in different ways. It is possible that other pine bark might have benefits where this one doesn't," he said.
In the United States and many other countries, government officials don't require natural dietary supplements to be proven safe and effective, the way other drugs are.
Stafford says his study illustrates10 how flimsy the scientific basis is for claims made by sellers of and advocates for many different supplements.
"Much of the expenditure11 on dietary supplements are for products that really don't have rigorous data supporting their use."
The study by Stanford researcher Randall Stafford and colleagues is published in the American Medical Association journal, Archives of Internal Medicine.
1 disorders | |
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调 | |
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2 prescription | |
n.处方,开药;指示,规定 | |
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3 random | |
adj.随机的;任意的;n.偶然的(或随便的)行动 | |
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4 randomly | |
adv.随便地,未加计划地 | |
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5 placebo | |
n.安慰剂;宽慰话 | |
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6 essentially | |
adv.本质上,实质上,基本上 | |
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7 noted | |
adj.著名的,知名的 | |
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8 nutritional | |
adj.营养的,滋养的 | |
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9 derived | |
vi.起源;由来;衍生;导出v.得到( derive的过去式和过去分词 );(从…中)得到获得;源于;(从…中)提取 | |
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10 illustrates | |
给…加插图( illustrate的第三人称单数 ); 说明; 表明; (用示例、图画等)说明 | |
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11 expenditure | |
n.(时间、劳力、金钱等)支出;使用,消耗 | |
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