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(单词翻译:双击或拖选)
Cardiac medicine has made tremendous strides since the 1950s, when surgeons placed the first experimental artificial valves in the human heart. One of the pioneers in that field is Dr. Albert Starr, who co-invented the heart value - which has extended the lives of millions of people. Early startAlbert Starr was just 16 when he enrolled1 at Columbia University in New York during World War II.
At that time, school offered accelerated programs for young men heading off to war. He finished in two years, and by the time he was 22, had completed medical school.
By then, World War II had ended, but the United States was involved in the Korean War so Starr decided2 to become a military doctor. Courtesy Albert StarrAlbert Starr (in helicopter) as a as a young surgeon in Korea"At first, I was a battalion3 surgeon on the front line, getting shot at. And then I was transferred to a mobile army surgical4 hospital, a MASH5 8076, and I spent a year there," says Starr. "During that year, I did more than 1000 major operations, just as a young kid. I mean, I was 23 years old."It was a perfect training ground for the future heart surgeon. After leaving the military, Starr moved into the new field of open-heart surgery.
New field"But it was very limited in scope because you couldn't take too long to do these operations. It would injure various vital organs, especially the brain," he says. "So we had to develop a mechanical device to imitate the lungs and the pumping action of the heart, the heart-lung machine, and it was that development that allowed the growth of open-heart surgery." Courtesy Albert StarrPioneering heart surgeon Albert Starr Researchers in Philadelphia developed that machine in the 1950s. It pumped oxygenated blood through the body, giving surgeons enough time to try to correct faulty heart valves, including the mitral valve inside the heart.
"We could put a patient on the heart-lung machine. We could open the left atrium. We could look at the mitral valve. Sometimes we could repair it. If we couldn't repair it, we had no alternative," says Starr. "There was nothing to fall back on, so valvular surgery without an artificial valve - at least as a backup - was a very dangerous game to play."At the University of Oregon Medical School, Starr got a visit one day from an eccentric engineer named Lowell Edwards. An inventor with many patents to his name, Edwards offered hope for a solution. Courtesy Albert StarrAlbert Starr with his co-inventor, Lowell Edwards Inventive partnership"He was a strange character, but I found out he was a great inventor, with a tremendous reputation. He had retired6 and had a lot of time on his hands and he wanted to develop an artificial heart."Starr convinced Edwards to narrow his focus and help develop a mechanical replacement7 for the heart's mitral valve, which controls blood flow within the heart.
The pair employed the latest space-age materials - Dacron, which was already used in heart grafts8, as well as Teflon and a flexible silicone called Silastic. Their device consisted of a ball inside a cage that moved back and forth9, in turn allowing the blood to flow inside or blocking it. The physician experimented with dogs and solved successive problems, from suture leaks to blood clots10. Courtesy Albert StarrAlbert Starr helped develop a mechanical replacement for the heart's mitral valve, which controls blood flow within the heart. Starr says he and Lowell also encountered non-surgical challenges as they moved through uncharted territory.
"We had to design everything, including the ethical11 elements, financial, clinical. We attacked one at a time, so the first thing we had to decide was, when we do our first human implant12?"Using heart valve in humansAs the laboratory test dogs survived longer and longer, Starr found himself doing human surgeries sooner than he expected.
"The chief of cardiology visits the animal laboratory and sees all these healthy dogs with mitral valve replacements13. And actually one of them sticks his head through the cage and licks his hand. Meanwhile, he's got a hospital full of patients in oxygen tents that need mitral valve replacement, and he said, 'You can't wait on this. We've got patients that need this device.'" Courtesy Albert StarrAlbert Starr with the heart valve he helped design.
Because Starr was operating on patients with terminal heart disease, there were many failures along the way. The first patient to receive a mitral valve implant, a woman in her 30s, died when an air bubble formed inside her heart. By the early 1960s, however, many of Starr's artificial mitral valve patients were successfully resuming their lives.
Today, hundreds of thousands of patients have had this type of implant, either the Starr-Edwards valve design or refinements14 on that model. Thousands of Starr's former patients send him updates through the social networking Internet site Facebook. Starr no longer does surgery, but is active as a medical consultant15, researcher and teacher. He looks back on the great strides in cardiac surgery over his six decades of practice - refinements in artificial heart valves, dramatic transplant operations and the widely used procedure of heart bypass surgery - proud to have played a part in developing techniques that have extended so many lives.
1 enrolled | |
adj.入学登记了的v.[亦作enrol]( enroll的过去式和过去分词 );登记,招收,使入伍(或入会、入学等),参加,成为成员;记入名册;卷起,包起 | |
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2 decided | |
adj.决定了的,坚决的;明显的,明确的 | |
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3 battalion | |
n.营;部队;大队(的人) | |
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4 surgical | |
adj.外科的,外科医生的,手术上的 | |
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5 mash | |
n.麦芽浆,糊状物,土豆泥;v.把…捣成糊状,挑逗,调情 | |
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6 retired | |
adj.隐退的,退休的,退役的 | |
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7 replacement | |
n.取代,替换,交换;替代品,代用品 | |
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8 grafts | |
移植( graft的名词复数 ); 行贿; 接穗; 行贿得到的利益 | |
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9 forth | |
adv.向前;向外,往外 | |
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10 clots | |
n.凝块( clot的名词复数 );血块;蠢人;傻瓜v.凝固( clot的第三人称单数 ) | |
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11 ethical | |
adj.伦理的,道德的,合乎道德的 | |
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12 implant | |
vt.注入,植入,灌输 | |
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13 replacements | |
n.代替( replacement的名词复数 );替换的人[物];替代品;归还 | |
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14 refinements | |
n.(生活)风雅;精炼( refinement的名词复数 );改良品;细微的改良;优雅或高贵的动作 | |
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15 consultant | |
n.顾问;会诊医师,专科医生 | |
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