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(单词翻译:双击或拖选)
A new study suggests that extreme malnutrition1 early in pregnancy2 may put a child at risk for Alzheimer's Disease decades later. The study begins not in the laboratory, but in the Netherlands during World War II.
At the end of 1944, Nazi3 occupation forces imposed a five-month food embargo4 in part of the Netherlands, in retaliation5 for a Dutch railroad strike aimed at disrupting German troop movements.
During the resulting famine, food rations6 were as little as 400 calories a day for residents - including pregnant women.
The children of those pregnancies7, the so-called Dutch famine birth cohort, have been followed closely in the decades since. Researchers have compared them in a series of studies with a control group of children born immediately before and after, to explore the long-term effects of their mothers' malnutrition during pregnancy.
In the latest research, done when the famine babies were in their late 50s, Susanne de Rooij and colleagues at the University of Amsterdam tested them for early signs of dementia.
They found little difference except in something called the Stroop test. That's a test where you are shown the word for one color printed in a different color, and you're asked to disregard the spelled-out color name and say the color that the word is printed in.
"And we found that the people who were exposed to the famine in the beginning of pregnancy, that they performed worse on these tasks," de Rooij explained. "And we think this is very interesting because a recent study has shown that this is one of the first things that may go wrong when you're developing Alzheimer's Disease later."
A study in the 1970s, when they were young army recruits, found no difference in intelligence between the famine and control groups.
But previous research has show physical health differences including increased obesity8, cardiovascular disease, and diabetes9 among the famine babies.
De Rooij's study wasn't designed to show the specific cause of any differences they discovered, but she says the fact that those most affected10 suffered malnutrition early in their gestation11 suggests one possibility.
"We think this is sort of an indication that as the central nervous system is being formed in the first part of pregnancy, that maybe something goes wrong due to the lack of nutrients12, that the central nervous system isn't really well constructed or [is] more sensitive to aging. So we think this may be happening, but of course we cannot be sure about that," she said.
Susanne de Rooij says she and other researchers will continue to follow the children of the World War II era famine as they age, to learn more about the effect of malnutrition during pregnancy.
1 malnutrition | |
n.营养不良 | |
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2 pregnancy | |
n.怀孕,怀孕期 | |
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3 Nazi | |
n.纳粹分子,adj.纳粹党的,纳粹的 | |
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4 embargo | |
n.禁运(令);vt.对...实行禁运,禁止(通商) | |
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5 retaliation | |
n.报复,反击 | |
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6 rations | |
定量( ration的名词复数 ); 配给量; 正常量; 合理的量 | |
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7 pregnancies | |
怀孕,妊娠( pregnancy的名词复数 ) | |
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8 obesity | |
n.肥胖,肥大 | |
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9 diabetes | |
n.糖尿病 | |
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10 affected | |
adj.不自然的,假装的 | |
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11 gestation | |
n.怀孕;酝酿 | |
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12 nutrients | |
n.(食品或化学品)营养物,营养品( nutrient的名词复数 ) | |
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