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(单词翻译:双击或拖选)
Scientists say they have successfully tested artificial blood vessels2 grown in the laboratory.
In a heart bypass operation, surgeons typically remove a vein3 from a patient's leg and use it to replace blocked arteries4 that feed the muscles of the heart. But what if, instead of cutting open the patient's leg, the surgeon used an artificial blood vessel1 that has been sitting in a hospital refrigerator? The new research suggests that day may soon come.
The artificial blood vessels are made by coating a biodegradable, plastic mesh5 tube with human or animal muscle cells. The cells produce a protein structure shaped like the plastic tube, which dissolves.
Shannon Dahl is co-founder of Humacyte, the North Carolina company that developed the artificial blood vessel. She explains that the next step is washing away the original muscle cells.
"So that what we're left with - the bioengineered vein - is just the proteins that the cell secreted6. This protein structure, the bioengineered vein, can be used in any human patient because the immunogenic part, the cells, have been removed," Dahl says.
The material is considered immunogenic since the protein structure won't be recognized by the recipient7 as foreign material.
The artificial grafts8 resist bursting and tearing in lab tests, but the real question is how they perform when used on an actual patient.
The research team implanted artificial vessels into a number of animals, doing heart bypass and other procedures. Alan Kypson, a surgeon at East Carolina University, did some of the implants9. A year later, the blood vessels were still performing well.
"It looked very similar, almost identical to the way it looked a year prior," Kypson says. "It didn't show any evidence of dilating10 or enlarging or calcifying11. And they were open, most importantly. They were patent, meaning there was no obstruction12 to blood flow in these bypasses."
According to Kypson, the artificial blood vessel would have advantages in heart bypass surgery because it doesn't require removal of a vein from a patient's leg. That means less time on the operating table, less chance of infection, and less pain for the patient.
1 vessel | |
n.船舶;容器,器皿;管,导管,血管 | |
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2 vessels | |
n.血管( vessel的名词复数 );船;容器;(具有特殊品质或接受特殊品质的)人 | |
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3 vein | |
n.血管,静脉;叶脉,纹理;情绪;vt.使成脉络 | |
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4 arteries | |
n.动脉( artery的名词复数 );干线,要道 | |
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5 mesh | |
n.网孔,网丝,陷阱;vt.以网捕捉,啮合,匹配;vi.适合; [计算机]网络 | |
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6 secreted | |
v.(尤指动物或植物器官)分泌( secrete的过去式和过去分词 );隐匿,隐藏 | |
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7 recipient | |
a.接受的,感受性强的 n.接受者,感受者,容器 | |
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8 grafts | |
移植( graft的名词复数 ); 行贿; 接穗; 行贿得到的利益 | |
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9 implants | |
n.(植入身体中的)移植物( implant的名词复数 ) | |
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10 dilating | |
v.(使某物)扩大,膨胀,张大( dilate的现在分词 ) | |
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11 calcifying | |
v.(使)钙化,(使)硬化( calcify的现在分词 ) | |
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12 obstruction | |
n.阻塞,堵塞;障碍物 | |
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