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(单词翻译:双击或拖选)
High-Tech1 Images Show How Viruses Infect Cells
At the University of Texas Medical School at Houston, Jun Liu uses a powerful electron microscope to examine E. coli bacteria and the tiny T-7 virus that infects them.
Liu says until now, scientists could only speculate on how this virus injected its genetic2 material into another cell, because it happens in an instant.
“Before they inject in, they do not have a channel. After they inject in, they actually degrade the channel, so you never have a chance to see it,” Liu said.
But in a collaborative study with other University of Texas colleagues, Liu used the electron microscope to examine quick-frozen solutions full of bacteria and viruses.
“Because when you freeze it, it is kind of like a snapshot that captures some intermediate stage. This is one of the highlights of this study, because we captured this intermediate stage that nobody had seen before,” Liu said.
This sophisticated technology was applied3 to a particular virus in this study, but what the researchers found could be useful in studying other viruses in the future, viruses that cause many diseases, such as influenza4, or AIDS.
That is the hope of study participant Ian Molineux, professor of biology at the University of Texas main campus in Austin, who prepared the virus samples used in the study.
“If we can find a way of blocking any of multiple steps towards the final internalization of the genetic material, it provides the potential for finding more anti-viral drugs,” Molineux said.
An animation5, produced for Science magazine by the American Association for the Advancement6 of Science, shows how the virus puts out tendrils to, in effect, “walk” on the cell surface.
"Then it stops moving and all the legs come down and get fixed7 on the cell surface, and the infection begins to initiate," Molineux said.
Molineux says the collaborative effort with Liu and others paid off, with each member of the team bringing his own area of expertise8 into play.
“We have a very strong collaboration9. We are looking at other viruses now,” Molineux said.
He says each advance in understanding how viruses function brings researchers closer to finding ways to defeat them - and save lives.
1 high-tech | |
adj.高科技的 | |
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2 genetic | |
adj.遗传的,遗传学的 | |
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3 applied | |
adj.应用的;v.应用,适用 | |
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4 influenza | |
n.流行性感冒,流感 | |
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5 animation | |
n.活泼,兴奋,卡通片/动画片的制作 | |
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6 advancement | |
n.前进,促进,提升 | |
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7 fixed | |
adj.固定的,不变的,准备好的;(计算机)固定的 | |
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8 expertise | |
n.专门知识(或技能等),专长 | |
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9 collaboration | |
n.合作,协作;勾结 | |
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