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Excessive regulation of genetically2 modified crops has delayed release of a variety of rice that could help reduce the leading cause of preventable blindness in children, according to an editorial published in the British journal Nature.
Vitamin A is essential for vision and a healthy immune system. The World Health Organization estimates that at least 250,000 children go blind each year from vitamin A deficiency, and half of them die within a year of losing their sight.
Rice doesn't naturally contain this essential nutrient4. That's why vitamin A deficiency is so common in parts of Africa and Southeast Asia, where rice is the mainstay of the diet.
Making rice golden
To tackle the problem, researchers took genes5 involved in producing beta carotene, a vitamin A precursor6, from other plant species and inserted them into rice. It gives the rice grains a yellow-orange color, and their name: Golden Rice.
When the project began in 1990, it was considered unlikely to succeed, says Golden Rice's co-inventor, Ingo Potrykus, a retired7 professor of plant sciences at the Swiss Federal Institute of Technology.
International Rice Research Institute
Flowers of a rice plant producing beta carotene
"It was considered far too ambitious because you had to transfer an unknown number of genes — at least six different genes — into rice. At that time people were happy to transfer a single gene3."
Potrykus says they had succeeded by 1999, but it will be 2012 at the earliest before Golden Rice is available to people who need it. He blames the delay on excessive regulation. He says an unreasonable8 amount of testing has been required, without scientific justificiation.
'Death and blindness'
"I therefore hold the regulation of genetic1 engineering responsible for the death and blindness of thousands of children and young mothers," he writes in the Nature editorial.
Potrykus wants the regulations changed because research institutes around the world are working on other important GM crops besides Golden Rice that could also help feed people in the developing world. However, he says, because bringing them to market takes 10 years longer and costs 10 times as much as a conventional crop, these crops are languishing9 on the shelves. He says now that some GM crops have been grown successfully for more than a decade, it's time to loosen the restrictions10.
"Despite claims of high risk of this material," he says, "there is not a single documented case of harm to any environment or any consumer."
'Scientific garbage'
Doug Gurian-Sherman, with the environmental group the Union of Concerned Scientists, calls that argument "scientific garbage." He says you can't say GM crops are safe because no one's really done a large-scale epidemiological study to see how people's bodies respond to them. He says they may very well be safe. But that won't be clear until they are tested.
"Potrykus' argument is like saying, 'Well, we've got these wonder drugs that could cure AIDS or cure malaria11 or cure whatever," says Gurian-Sherman, "but let's not do any testing on them because there's people suffering in the meantime.'"
Gurian-Sherman says one reason Golden Rice needs to be tested for safety is because vitamin A and its chemical relatives can be toxic12 at high levels.
Carrot poisoning
Others don't see that as a convincing argument.
"It's like saying if you ate too many carrots you could get vitamin A poisoning. It just doesn't happen," says Howarth Bouis, director of a project called Harvest Plus, which is working to breed more nutritious13 crops for the developing world.
Bouis is on the board of the Golden Rice project. But he says Harvest Plus decided14 to stay away from using GM technology because regulations would slow progress.
"I think we're going to make some good progress with conventional breeding that we couldn't have made with transgenics simply because of the regulatory systems in place."
For example, researchers are developing vitamin A-rich maize15 using conventional breeding. While regulators require extensive testing on GM Golden Rice, the new fortified16 maize varieties won't raise an eyebrow17.
Doug Gurian-Sherman of the Union of Concerned Scientists says GM technology is inherently more costly18 and time-consuming than conventional breeding. He would prefer to see more of the limited resources available for agriculture research spent on conventional means of tackling malnutrition19. But if tests show Golden Rice is safe and effective, he says it should be considered.
The question will be, how much testing is enough?
1 genetic | |
adj.遗传的,遗传学的 | |
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2 genetically | |
adv.遗传上 | |
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3 gene | |
n.遗传因子,基因 | |
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4 nutrient | |
adj.营养的,滋养的;n.营养物,营养品 | |
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5 genes | |
n.基因( gene的名词复数 ) | |
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6 precursor | |
n.先驱者;前辈;前任;预兆;先兆 | |
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7 retired | |
adj.隐退的,退休的,退役的 | |
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8 unreasonable | |
adj.不讲道理的,不合情理的,过度的 | |
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9 languishing | |
a. 衰弱下去的 | |
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10 restrictions | |
约束( restriction的名词复数 ); 管制; 制约因素; 带限制性的条件(或规则) | |
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11 malaria | |
n.疟疾 | |
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12 toxic | |
adj.有毒的,因中毒引起的 | |
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13 nutritious | |
adj.有营养的,营养价值高的 | |
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14 decided | |
adj.决定了的,坚决的;明显的,明确的 | |
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15 maize | |
n.玉米 | |
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16 fortified | |
adj. 加强的 | |
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17 eyebrow | |
n.眉毛,眉 | |
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18 costly | |
adj.昂贵的,价值高的,豪华的 | |
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19 malnutrition | |
n.营养不良 | |
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