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Targeted Treatment May Improve Odds1 for Breast Cancer Patients
WASHINGTON—
New research could change the way breast cancer is treated.
When Shante Thomas was diagnosed with Stage 2 breast cancer, it came as a complete shock.
"Am I going to die? Honestly, that's the first thing you think," she recalled.
With the right treatment, though, many women can expect to beat the disease; but, with more than 50 drugs to choose from, it's hard for doctors to know which ones will work best for any individual. Add to that the fact that cancer-fighting drugs are highly toxic2 and kill healthy cells along with the cancerous ones.
Right now, choosing the right drug is a guessing game; but, that may not always be the case. Alex Walsh is one of the researchers at Vanderbilt University using lasers to study tumor3 particles called "organoids."
"Organoids are small pieces of tumor that we grow in a petri dish, and they’re about 100 to 300 micrometers in diameter," said Walsh.
The tumor cells are microscopic4. When given a collagen gel, they grow just as they would inside a human body. The cells are naturally fluorescent5. So when the researchers add a cancer fighting drug, they can tell how well the drug works by measuring the amount of fluorescence. If a drug works, there are fewer cancer cells and less fluorescence.
"Our idea was to try to eliminate toxicities from ineffective treatments and then use drugs that are more effective in treating breast cancer," said Professor Melissa Skala, the lead researcher.
Skala said the hope is that with a more effective drug at the start of treatment, doctors can ultimately improve the survival of breast cancer patients.
“We know a lot of breast cancer patients initially6 respond to their therapy and then later, their tumor starts to grow and they succumb7 to their disease," said Skala.
Skala added that the next step is to see if the researchers can accurately8 predict which drugs will work before a patient is treated.
The hope is that this type of targeted therapy could be available to breast cancer patients in five to 10 years. Then, people like Shante Thomas won't automatically think a diagnosis9 of breast cancer is a death sentence.
1 odds | |
n.让步,机率,可能性,比率;胜败优劣之别 | |
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2 toxic | |
adj.有毒的,因中毒引起的 | |
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3 tumor | |
n.(肿)瘤,肿块(英)tumour | |
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4 microscopic | |
adj.微小的,细微的,极小的,显微的 | |
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5 fluorescent | |
adj.荧光的,发出荧光的 | |
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6 initially | |
adv.最初,开始 | |
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7 succumb | |
v.屈服,屈从;死 | |
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8 accurately | |
adv.准确地,精确地 | |
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9 diagnosis | |
n.诊断,诊断结果,调查分析,判断 | |
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