2007年VOA标准英语-New Study Recommends All Women Under 50 with Br

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By Carol Pearson
Washington, D.C.
22 June 2007
 

Studies show that women with a strong family history of breast cancer -- meaning their mothers, sisters, aunts or grandmothers had the disease -- have a higher risk of getting breast cancer, too.  But a new study shows any woman who gets the disease before she turns 50 could also have a high risk of getting cancer in her other breast or in her ovaries, even if there is no family history of these diseases.  VOA's Carol Pearson explains.

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Nearly 14 percent of breast cancer patients without a family history of breast cancer tested positive for the mutated gene

When breast cancer seems to run in a family, it is possible the disease is passed along by a mutated gene.

But a new study published in the Journal of the American Medical Association shows family history does not always tell the whole story.

Dr. Jeffrey Weitzel and his colleagues at the City of Hope Cancer Center in California, studied more than 1500 breast cancer patients.  Most got breast cancer before they turned 50. 

The study showed nearly 14 percent of breast cancer patients without a family history of this disease tested positive for the mutated gene. 

Dr. Jeffrey Weitzel

Dr. Weitzel says the greatest finding is that fathers, as well as mothers, can pass this mutated gene to their daughters.

"What we showed was that if you had a limited family structure, not enough women in the family to help see the trait, that you were three times more likely to be a carrier," says Weitzel.

Women with this mutated gene have a 50 to 85 percent chance of developing breast cancer over their lifetimes compared to a ten percent chance for those without the mutation². They are also at higher risk for developing ovarian cancer.  Their doctors often recommend genetic³ testing, and if the test is positive, they offer more thorough cancer screening.

Genetic testing may become more common

But genetic testing is usually offered only to women with a strong family history of breast cancer. Dr. Weitzel recommends offering genetic testing to all women who develop breast cancer early in life.

"We want to be sure and offer testing to women who had early onset⁴ breast cancer, despite the lack of a family history," adds Weitzel.

Michele Rakoff survived breast cancer.  She does not have the gene, but she speaks out for those who have the disease. "We need to make sure that women are aware that you can get a genetic mutation through the line of your father as well as your mother," says Rakoff.

Dr. Weitzel agrees.  He says if a woman is diagnosed with breast cancer early in life, genetic testing could help save her life.