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The new coronavirus COVID-19 made Dr. Jag Singh a patient at his own hospital.
A lung infection made it difficult for him to breathe. His doctors at Massachusetts General said he needed to make a decision about life support while in intensive care.
Then, they offered him a chance to test remdesivir. The experimental drug has had some good results when used against other coronaviruses. Singh, a heart specialist, said ‘yes' immediately.
COVID-19 patients around the world have been joining remdesivir studies in the past few weeks.
The interest has been so great that the U.S. National Institutes of Health (NIH) is expanding its study. It has nearly reached its first goal of 440 patients. The California company Gilead Sciences makes the drug. It is increasing its own studies too.
"I would enroll1 my family" immediately, said Dr. Libby Hohmann. She placed Singh and nearly 30 other patients in the NIH study at Massachusetts General.
For most people, COVID-19 causes moderate symptoms. Some patients, however, get a lung infection which requires hospitalization. The risk of death is greater for older people and those with other health problems.
The drug remdesivir has been used in animal testing against two similar coronaviruses, SARS and MERS. The drug helped prevent infection and reduced the symptoms if it was taken early. The testing is farther along than other possible drugs and may lead to government approval for treatment.
The drug-maker Gilead has given remdesivir to more than 1,700 patients. Its chief executive2 Dan O'Day wrote that many people have asked for the drug but the company is "taking the ethical3, responsible approach." He said more people will be helped if studies prove the drug to be safe and effective.
O'Day said his company has drug treatment for more than 140,000 patients. It is providing the drug for free for now. It has set a goal of making treatments for 500,000 patients by October and more than a million by the end of the year.
Gilead also gave remdesivir to China for two studies expected to have results by the end of the month. Other studies have begun in Asia and Europe.
"There's so much anxiety about the disease that the patients are quite interested" and no one offered the chance has refused, said Dr. Arun Sanyal. He is the study leader at Virginia Commonwealth4 University in Richmond.
The NIH study, however, is the most rigorous5 of all the tests. It compares remdesivir to placebos6, and neither patients nor doctors know who is getting what until the end of the study.
Words In This Story
enroll – v. to join or to take part in something
symptom – n. a change in the body or mind which indicates that a disease is present
anxiety – n. fear or nervousness about what may happen
rigorous – adj. doing something with a lot of interest and strength
placebo– n. a pill or substance that is given to a patient like a drug but that has no physical effect on the patient
1 enroll | |
v.招收;登记;入学;参军;成为会员(英)enrol | |
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2 executive | |
adj.执行的,行政的;n.执行者,行政官,经理 | |
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3 ethical | |
adj.伦理的,道德的,合乎道德的 | |
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4 commonwealth | |
n.共和国,联邦,共同体 | |
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5 rigorous | |
adj.严密的,缜密的,严格的,严厉的 | |
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6 placebos | |
n.(给无实际治疗需要者的)安慰剂( placebo的名词复数 );安慰物;宽心话;(试验药物用的)无效对照剂 | |
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