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Pfizer-BioNTech seek FDA authorization1 for 2nd COVID booster for older adults
Pfizer says it will soon submit data on a fourth COVID shot to the Food and Drug Administration. What is the case for another booster, and is there a downside to the approach?
A MARTINEZ, HOST:
Numbers from the CDC show nearly 67% of fully3 vaccinated4 people over the age of 65 have gotten a booster shot. Pfizer and BioNTech want the FDA to authorize5 yet another one for that age group. NPR health correspondent Rob Stein says the idea is to bolster6 waning7 immunity8.
ROB STEIN, BYLINE9: It's become clear that the protection people get from three shots fades over time, especially against catching10 the virus. And that's especially true with omicron, which is better at evading11 the immune system than earlier versions of the virus. Now, you know, three shots still do a very good job of keeping most people from getting so sick they end up in a hospital or die, but there has been rising concern about those who are the most vulnerable, like the elderly. They tend to have weaker immune systems to start with, so some other countries have started giving older people yet another booster.
MARTINEZ: So what do you think? I mean, is the FDA likely to authorize another booster?
STEIN: You know, it really depends on how strong a case the agency thinks the companies are making. It's based on two studies from Israel that have produced some evidence that a fourth shot could help pump the immune system back up and restore some protection against getting seriously ill. I talked about this with Dr. Eric Topol at Scripps Research. He's convinced there's enough evidence to warrant another round of boosters.
ERIC TOPOL: We need to move on this because there are a large number of people who have lost their protection against severe illness from omicron and future variants13.
STEIN: So Topol thinks it's urgent to start making another booster available to the elderly, especially in case omicron starts to surge again or another dangerous variant12 emerges.
MARTINEZ: But not everyone is as convinced as Dr. Topol.
STEIN: Yeah, that's right. That's right. Many experts I've been talking with basically say it may still be just too premature14 to start another round of boosters. They say the Israeli data is far from a slam dunk that another shot is necessarily needed and would necessarily help. Here's Dr. Jesse Goodman. He's a former FDA chief scientist who's now at Georgetown University.
JESSE GOODMAN: I think you'd want to have really convincing evidence that a second booster was needed and beneficial, and we just don't have that yet. I don't think we know that a booster will not ultimately be required generally, but I think we're just not there yet.
STEIN: And some experts I talked to say the country should focus instead on getting the millions of people who are still not vaccinated at all to get their shots and get boosters into the arms of the millions of vaccinated people who still haven't gotten their third shots. You know, only about two-thirds of those age 65 and older have gotten their third shots, their boosters.
MARTINEZ: All right, Rob, so what happens now?
STEIN: The FDA will consider the request and make a decision. You know, the agency could ask a committee of outside advisers15 to give advice, but it doesn't necessarily have to. And one possibility is that the FDA authorizes16 the fourth shot and then leaves it up to the CDC about whether to recommend it or, you know, just have it ready for whenever the evidence becomes clear it's really needed. The FDA is, however, planning to convene17 outside advisers next month to consider where we go from here with the vaccines19 more generally, including whether we need a broader booster campaign, perhaps in the fall, that would include younger people, too. They may also discuss whether those shots should be annual or, you know, the same vaccine18 or something else, like a vaccine targeted specifically at variants or maybe at, you know, protecting people against all coronaviruses.
MARTINEZ: That's NPR health correspondent Rob Stein. Rob, thanks a lot.
STEIN: You bet.
1 authorization | |
n.授权,委任状 | |
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2 transcript | |
n.抄本,誊本,副本,肄业证书 | |
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3 fully | |
adv.完全地,全部地,彻底地;充分地 | |
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4 vaccinated | |
[医]已接种的,种痘的,接种过疫菌的 | |
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5 authorize | |
v.授权,委任;批准,认可 | |
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6 bolster | |
n.枕垫;v.支持,鼓励 | |
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7 waning | |
adj.(月亮)渐亏的,逐渐减弱或变小的n.月亏v.衰落( wane的现在分词 );(月)亏;变小;变暗淡 | |
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8 immunity | |
n.优惠;免除;豁免,豁免权 | |
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9 byline | |
n.署名;v.署名 | |
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10 catching | |
adj.易传染的,有魅力的,迷人的,接住 | |
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11 evading | |
逃避( evade的现在分词 ); 避开; 回避; 想不出 | |
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12 variant | |
adj.不同的,变异的;n.变体,异体 | |
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13 variants | |
n.变体( variant的名词复数 );变种;变型;(词等的)变体 | |
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14 premature | |
adj.比预期时间早的;不成熟的,仓促的 | |
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15 advisers | |
顾问,劝告者( adviser的名词复数 ); (指导大学新生学科问题等的)指导教授 | |
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16 authorizes | |
授权,批准,委托( authorize的名词复数 ) | |
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17 convene | |
v.集合,召集,召唤,聚集,集合 | |
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18 vaccine | |
n.牛痘苗,疫苗;adj.牛痘的,疫苗的 | |
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19 vaccines | |
疫苗,痘苗( vaccine的名词复数 ) | |
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