60秒科学:克隆氏病不仅仅由基因决定,病毒感染起

Mice with a genetic² predisposition to get a Crohn's-like disease were kept healthy until exposed to a virus that apparently³ triggers the condition.

Crohn’s disease is a real pain in the gut⁴. This inflammatory disorder⁵ can lead to some serious intestinal⁶ difficulties. And heredity is partly to blame: some 30 different genes⁷ enhance susceptibility. But not everyone who has the genes gets Crohn’s.

Now scientists find that those with one type of risky⁸ gene¹ may also need to catch a virus to trigger the disease. The results appear in the journal Cell.

Doctors have long suspected that some sort of virus might precipitate⁹ autoimmune disorders¹⁰, like lupus or multiple sclerosis. But in the case of Crohn’s, researchers stumbled across the connection by accident.

They were studying mice that carry a version of a gene associated with Crohn’s. These animals develop gut problems similar to those seen in humans. Then the researchers started keeping the animals in clean cages. Really clean cages, in which the bedding, food, and water are sterilized¹¹. And the squeaky clean mice, even with the risky gene, stayed healthy. But when the scientists exposed the animals to a common virus, they came down with mouse Crohn’s.

The research shows that some illnesses may require a combination of genetic predisposition and infection. Info which could lead to new treatment strategies
 

1 gene   

n.遗传因子，基因

参考例句：

• A single gene may have many effects.单一基因可能具有很多种效应。
• The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。

2 genetic   

adj.遗传的，遗传学的

参考例句：

• It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
• Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。

3 apparently   

adv.显然地；表面上，似乎

参考例句：

• An apparently blind alley leads suddenly into an open space.山穷水尽，豁然开朗。
• He was apparently much surprised at the news.他对那个消息显然感到十分惊异。

4 gut   

n.[pl.]胆量；内脏；adj.本能的；vt.取出内脏

参考例句：

• It is not always necessary to gut the fish prior to freezing.冷冻鱼之前并不总是需要先把内脏掏空。
• My immediate gut feeling was to refuse.我本能的直接反应是拒绝。

5 disorder   

n.紊乱，混乱；骚动，骚乱；疾病，失调

参考例句：

• When returning back,he discovered the room to be in disorder.回家后，他发现屋子里乱七八糟。
• It contained a vast number of letters in great disorder.里面七零八落地装着许多信件。

6 intestinal   

adj.肠的；肠壁；肠道细菌

参考例句：

• A few other conditions are in high intestinal obstruction. 其它少数情况是高位肠梗阻。 来自辞典例句
• This complication has occasionally occurred following the use of intestinal antiseptics. 这种并发症偶而发生在使用肠道抗菌剂上。 来自辞典例句

7 genes   

n.基因( gene的名词复数 )

参考例句：

• You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因，所以能够活得很长。 来自《简明英汉词典》
• Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪

8 risky   

adj.有风险的，冒险的

参考例句：

• It may be risky but we will chance it anyhow.这可能有危险，但我们无论如何要冒一冒险。
• He is well aware how risky this investment is.他心里对这项投资的风险十分清楚。

9 precipitate   

adj.突如其来的；vt.使突然发生；n.沉淀物

参考例句：

• I don't think we should make precipitate decisions.我认为我们不应该贸然作出决定。
• The king was too precipitate in declaring war.国王在宣战一事上过于轻率。

10 disorders   

n.混乱( disorder的名词复数 )；凌乱；骚乱；（身心、机能）失调

参考例句：

• Reports of anorexia and other eating disorders are on the increase. 据报告，厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
• The announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》

11 sterilized   

v.消毒( sterilize的过去式和过去分词 )；使无菌；使失去生育能力；使绝育

参考例句：

• My wife was sterilized after the birth of her fourth child. 我妻子生完第4个孩子后做了绝育手术。 来自辞典例句
• All surgical instruments must be sterilized before use. 所有的外科手术器械在使用之前，必须消毒。 来自辞典例句