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(单词翻译:双击或拖选)
This is Scientific American's 60-Second Science, I'm Steve Mirsky. Got a minute?
A strain of mutant mice groom1 compulsively till they seriously injure themselves. The condition is considered a good animal model for OCD, and it’s similar to the human disorder2 trichotillomania, where people pull out their own hair. Now researchers have successfully treated this pathological behavior in the mice—with a bone marrow3 transplant. The work, led by Nobel Laureate Mario Capecchi, was published in the journal Cell.
The mouse condition is related to immune system cells called microglia. These cells originate in the bone marrow and wind up in the brain, where their job is to fight off infections. But a genetic4 mutation5 leads to defective6 microglia, which drive the mice to perform the odd, self-mutilating behavior.
The researchers gave 10 mutant mice bone marrow from healthy mice. And the presence of normal microglia stopped the compulsion. It’s compelling evidence for the long-proposed link between the immune system and certain psychiatric disorders7.
Capecchi warns that bone marrow transplants are too risky8 to be commonly used against, for example, OCD. Rather, a fuller understanding of the immune system-mental illness connection should produce new treatments.
Thanks for the minute for Scientific American’s 60-Second Science. I’m Steve Mirsky.
1 groom | |
vt.给(马、狗等)梳毛,照料,使...整洁 | |
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2 disorder | |
n.紊乱,混乱;骚动,骚乱;疾病,失调 | |
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3 marrow | |
n.骨髓;精华;活力 | |
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4 genetic | |
adj.遗传的,遗传学的 | |
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5 mutation | |
n.变化,变异,转变 | |
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6 defective | |
adj.有毛病的,有问题的,有瑕疵的 | |
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7 disorders | |
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调 | |
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8 risky | |
adj.有风险的,冒险的 | |
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