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Some 70 million American adults have high blood pressure. Three quarters of them rely on medication to keep the condition in check. But you've got to remember to actually take the daily dose. Now researchers have devised a longer-lasting alternative: a vaccine1 to lower blood pressure...for rats, at least.
Scientists jabbed hypertensive rates with three doses of the formulation. It's a DNA2 vaccine, containing DNA fragments from angiotensin II—a hormone3 that boosts blood pressure as well as fragments from hepatitis B, to guarantee the immune system's attention. Cells suck up the vaccine's DNA and start pumping out the proteins the DNA codes for. When the host's defenses get a whiff (a smell that is only smelled briefly4 or faintly) from the proteins, it reacts. It really revs5 up (make or become active or energetic) against the hepatitis B fragments, and while it's at it, it starts taking out some angiotensin II as well.
The result is a reduction of angiotensin II's usual blood raising effect, similar to what blood pressure meds like Benicar do. Less angiotensin II means more relaxed blood vessels6 and a drop in pressure. That effect lasted six months in the vaccinated7 rats, and lengthened8 their lifespan by eight weeks. Necropsies on the vaccinated rats revealed healthier heart tissue than normally found with high blood pressure, and no damage to the kidneys or livers. The results are in the journey Hypertension.
Other blood pressure vaccines9 have been tried, unsuccessfully, but this naval10 DNA-based vaccine could induce (bring about or give rise to) longer-lasting effect, and the hope of twice yearly shot instead of daily pills.
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1 vaccine | |
n.牛痘苗,疫苗;adj.牛痘的,疫苗的 | |
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2 DNA | |
(缩)deoxyribonucleic acid 脱氧核糖核酸 | |
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3 hormone | |
n.荷尔蒙,激素,内分泌 | |
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4 briefly | |
adv.简单地,简短地 | |
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5 revs | |
abbr.revolutions (复数)旋转,回转,转数n.发动机的旋转( rev的名词复数 )v.(使)加速( rev的第三人称单数 );(数量、活动等)激增;(使发动机)快速旋转;(使)活跃起来 | |
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6 vessels | |
n.血管( vessel的名词复数 );船;容器;(具有特殊品质或接受特殊品质的)人 | |
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7 vaccinated | |
[医]已接种的,种痘的,接种过疫菌的 | |
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8 lengthened | |
(时间或空间)延长,伸长( lengthen的过去式和过去分词 ) | |
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9 vaccines | |
疫苗,痘苗( vaccine的名词复数 ) | |
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10 naval | |
adj.海军的,军舰的,船的 | |
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