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(单词翻译:双击或拖选)
By Barry Unger
Washington, DC
03 February 2006
watch Bird Flu Research report
There are two new, experimental vaccines2 against bird flu that both make use of a cold virus and that both may work even if the bird flu virus mutates.
In a study published in a British medical journal (the Lancet) researchers in the U.S. used a human cold virus, or adenovirus that was changed so it could not make copies of itself, to produce a bird flu protein that seems to stimulate3 a more powerful immune response than normal flu vaccines. Both it and a vaccine1 developed at the University of Pittsburgh can be produced more quickly than traditional vaccines as well, because they are not cultured in eggs. The Pittsburgh researchers used the cold virus and bird flu DNA4 to immunize mice and chickens.
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The deadly strain of the bird flu virus has killed over 80 people and led to the destruction of millions of fowl5 worldwide. The disease continues to spread.
There are several bird flu vaccines currently being developed, but researchers at the University of Pittsburgh have announced they have developed a vaccine that works on animals, and can be created quickly.
Swabing inside of mouth of bird
Researchers used genes6 from the bird flu virus and combined them with the common cold virus to create the vaccine. They then injected the vaccine in chickens. The chickens were later infected with avian flu, but none of them got sick.
Dr. Andrea Gambotto, with the University of Pittsburgh School of Medicine says the vaccine has tested 100 percent effective, "We have proven that this vaccine is 100% effective in both chickens and mice."
Their vaccine was genetically7 engineered and was manufactured in only 36 days, as opposed to current flu vaccines, which take months to develop. The only drawback is that this new technology will not be widely available for several years.
Scientists, Dr. Gregory Poland with the Mayo Clinic believe it's an important step forward in fighting pandemics. "You can see the context of, an emergency of a pandemic, the importance of being able to produce a vaccine in weeks versus8 months, the way we currently do it."
These potential vaccines hold promise for the future, according to Dr. Gary Nabel of the US National Institutes of Health.
"We're now moving forward with a lot of new approaches to flu. And the good news here is we've identified another one that appears to work."
The Pittsburgh researchers believe their vaccine will still be effective in protecting chickens even if the virus mutates.
1 vaccine | |
n.牛痘苗,疫苗;adj.牛痘的,疫苗的 | |
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2 vaccines | |
疫苗,痘苗( vaccine的名词复数 ) | |
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3 stimulate | |
vt.刺激,使兴奋;激励,使…振奋 | |
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4 DNA | |
(缩)deoxyribonucleic acid 脱氧核糖核酸 | |
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5 fowl | |
n.家禽,鸡,禽肉 | |
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6 genes | |
n.基因( gene的名词复数 ) | |
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7 genetically | |
adv.遗传上 | |
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8 versus | |
prep.以…为对手,对;与…相比之下 | |
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