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Study: Vitamin D is Powerful Weapon Against TB
Vitamin D plays a critical role in fighting infection and now scientists say that it may be a powerful weapon against tuberculosis1.
In a study reported in the journal Science Translational Medicine, researchers studied how T-cells - a kind of white blood cell that fights infection - are especially effective against the bacteria that cause tuberculosis.
People with low vitamin D levels are more susceptible2 to infection. It’s also known that people with reduced immunity3 - like those with HIV, the virus that causes AIDS - are more susceptible to tuberculosis.
Robert Modlin, chief of dermatology at the University of California Los Angeles School of Medicine and study co-author says the researchers examined that connection.
“And through that, we discovered that one particular type of T-cell, the one that secreted4 a protein called interferon-gamma, was able to activate5 white blood cells that were infected with the tuberculosis bacteria to then kill the bacteria.”
But Modlin says it required vitamin D. “People that had low levels of vitamin D in their blood were unable to mount this mechanism6 and kill the bacteria.”
In lab experiments, scientists supplemented blood samples that were deficient7 in vitamin D. That activated8 the T-cells to destroy the TB bacteria.
Modlin says the findings could lead to new therapies using supplements to prevent TB or help in its treatment. “I think it could change how we think about vitamin D supplementation.”
The paper also notes that while the skin absorbs vitamin D naturally from the sun, it takes more exposure for African Americans to reach the same level of vitamin D as white individuals.
But too much sun can lead to skin cancer. So Modlin recommends supplements over sun exposure, while cautioning that high doses can be toxic9.
“I recommend that people consult with their internal medicine doctor and perhaps have their vitamin D levels measured if they think that’s appropriate and institute the right supplementation for them.”
Modlin says the next step is to initiate10 clinical trials to learn whether vitamin D supplements can augment11 resistance to tuberculosis or other infections.
1 tuberculosis | |
n.结核病,肺结核 | |
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2 susceptible | |
adj.过敏的,敏感的;易动感情的,易受感动的 | |
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3 immunity | |
n.优惠;免除;豁免,豁免权 | |
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4 secreted | |
v.(尤指动物或植物器官)分泌( secrete的过去式和过去分词 );隐匿,隐藏 | |
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5 activate | |
vt.使活动起来,使开始起作用 | |
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6 mechanism | |
n.机械装置;机构,结构 | |
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7 deficient | |
adj.不足的,不充份的,有缺陷的 | |
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8 activated | |
adj. 激活的 动词activate的过去式和过去分词 | |
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9 toxic | |
adj.有毒的,因中毒引起的 | |
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10 initiate | |
vt.开始,创始,发动;启蒙,使入门;引入 | |
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11 augment | |
vt.(使)增大,增加,增长,扩张 | |
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