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(单词翻译:双击或拖选)
Some Fatty Foods Trigger Natural High
Ever wonder why foods that are bad for you - such as fat-laced potato chips and French fries - taste so good? It turns out they follow the same pleasure-inducing biochemical pathways through the body as marijuana does, encouraging people to keep eating even when they know they should stop.
There used to be an old television commercial in the United States that boasted a certain brand of potato chip tasted so good, you could never eat just one. It turns out there is a biological reason for that.
Fat is an important component1 of healthy human cell membranes2 and high-fat foods, which are rare in the wild, and were prized by early humans as a rich source of energy. As a result, says Daniele Piomelli at the University of California, Irvine, humans developed a biological preference for fatty foods.
"The mechanisms3 that have evolved to make animals eat as much as possible now are turning against us because now fat is everywhere," says Piomelli. "We have fat in our refrigerators, in our cabinets in the kitchen and it is very easy for us to eat too much of it because of this long evolution that has taught us that it is rare and hard to find."
Piomelli's team has discovered a biological pathway that encouraged ancient humans to eat large quantities of the scarce nutrient4 - whenever they found it - to ensure their survival. Today, eating fat still provokes feelings of pleasure and satisfaction, similar to the high people get when smoking marijuana.
According to Piomelli, when fatty foods are swallowed and hit the upper digestive tract5, they trigger the production of endocannabinoids. That's the same class of feel-good brain chemicals that marijuana, or cannabis, stimulates6 in the brain.
Endocannabinoids in the gut7 send a surge of cell-signaling to the brain, which shoots back a message telling the body to keep eating.
Piomelli's team discovered the fat pathway in research with rats. The rats didn't like sugar water or water laced with protein as much as they liked oily water. The animals continued to consume the oil water until they were full, which is the body's natural signal to stop eating.
But since fats contain more calories than carbohydrates8 or proteins combined, waiting for satiety9, or fullness, is not necessarily the best strategy to limit consumption of fatty foods.
Piomelli says researchers are interested in developing drugs that target endocannabinoids in the digestive tract to help people with their fatty food cravings.
"When some people eat fat, they eat it in large amounts - for example a pint10 of ice cream or a whole bag of potato chips. And hopefully by using these type of medications, we can decrease overweight and obesity11."
1 component | |
n.组成部分,成分,元件;adj.组成的,合成的 | |
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2 membranes | |
n.(动物或植物体内的)薄膜( membrane的名词复数 );隔膜;(可起防水、防风等作用的)膜状物 | |
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3 mechanisms | |
n.机械( mechanism的名词复数 );机械装置;[生物学] 机制;机械作用 | |
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4 nutrient | |
adj.营养的,滋养的;n.营养物,营养品 | |
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5 tract | |
n.传单,小册子,大片(土地或森林) | |
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6 stimulates | |
v.刺激( stimulate的第三人称单数 );激励;使兴奋;起兴奋作用,起刺激作用,起促进作用 | |
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7 gut | |
n.[pl.]胆量;内脏;adj.本能的;vt.取出内脏 | |
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8 carbohydrates | |
n.碳水化合物,糖类( carbohydrate的名词复数 );淀粉质或糖类食物 | |
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9 satiety | |
n.饱和;(市场的)充分供应 | |
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10 pint | |
n.品脱 | |
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11 obesity | |
n.肥胖,肥大 | |
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