VOA慢速英语--Moderna Inc已向美国申请COVID-19疫苗紧急使用授权

Moderna Seeks Emergency Approval for COVID-19 Vaccine¹

From VOA Learning English, this is the Health & Lifestyle report.

The American drug-maker Moderna said Monday it has requested emergency use permission from the U.S. Food and Drug Administration (FDA) for its COVID-19 vaccine. It has also asked for conditional² approval from the European Medicines Agency (EMA).

Moderna's request comes just 10 days after Pfizer and its German partner BioNTech sought emergency use approval for its vaccine in the United States and across Europe.

In addition, Britain is looking at data from the Oxford-AstraZeneca vaccine trial for a possible emergency approval.

Early data from the Moderna and Pfizer studies show that both vaccine candidates are nearly 95 percent effective against COVID-19. Britain's Oxford-AstraZeneca group says its vaccine candidate is between 62 to 90 percent effective, depending on how the vaccine is given.

The FDA requires that a vaccine be at least 50 percent effective in order to be considered for emergency use.

None of the three groups has published complete data from their large Phase 3 studies in scientific papers.

Question raised about AstraZeneca vaccine

On November 23, the Oxford-AstraZeneca group said its vaccine treatment of a half first dose followed by a full second dose one month later was found to be 90 percent effective. The treatment involving a full dose both times was found to be 62 percent effective.

Scientists, however, remain concerned about the small number of volunteers who received the half first dose.

AstraZeneca told the Reuters news agency that the smaller half dose treatment was at first given to volunteers by mistake. But it said that there should be "no concern." And, it added that independent scientists and regulators have studied and approved the half dose treatment.

AstraZeneca chief Pascal Soriot said last week that the drug-maker was likely to run more trials to study the effectiveness of its vaccine treatment using the half first dose.

What's next?

A group of independent scientists known as the Vaccines³ and Related Biological Products Advisory⁴ Committee (VRBPAC) will now study results from Moderna's and Pfizer's Phase 3 trials. The group will advise the FDA on the safety and effectiveness of the vaccine candidates.

On December 10, the FDA will meet to consider Pfizer's emergency use request. The agency plans to look at Moderna's request one week later.

If the FDA approves its request, Moderna expects to have 20 million treatments by the end of 2020. Since the treatment requires two shots, that will be enough for 10 million people.

Pfizer says it can supply 50 million vaccine treatments by the end of 2020, enough for 25 million people. It hopes to produce up to 1.3 billion treatments by the end of 2021.

Based on agreements with the U.S. government, vaccines from Moderna and Pfizer will cost between $15 and $25 a treatment. Oxford-AstraZeneca's vaccine will cost under $4.

Unlike vaccine candidates from Pfizer and Moderna, the vaccine from the Oxford-AstraZeneca group does not require extreme-cold storage. This, along with its lower cost, makes the vaccine a good candidate for many countries around the world. The drug-maker added it will also seek "an Emergency Use Listing from the World Health Organization (WHO)" to make the vaccine available sooner.

General Gustave Perna is chief operations officer for the U.S. Operation Warp⁵ Speed program. He said that a COVID-19 vaccine would begin to be sent out within 24 hours of FDA approval.

Many do not trust vaccines

Johns Hopkins University's Coronavirus Resource Center reports that nearly 63 million people have now been infected with COVID-19. Nearly 1.5 million have died from the disease.

With several vaccine candidates seeking emergency use approval, the next step is for governments and health officials to prepare for mass vaccinations⁶ worldwide. That may not be easy.

Many people do not trust the safety of COVID-19 vaccines, a June 2020 study by Nature Medicine found. The study collected information from more than 13,000 people in 35 countries.

The study asked participants whether they would "accept a vaccine if it were recommended by your employer and was approved safe and effective by the government." Only 31.9 percent of participants answered "completely agree."

In the United States, a USA Today/Suffolk survey from August found that two-thirds of Americans said they would not get a COVID-19 vaccine.

And that's the Health & Lifestyle report.

Word in This Story

phase - n. a step in the process

dose - n. the amount of medicine that is taken at one time

regulator - n. a government official that controls a public activity by making and enforcing rules

participant - n. a person who is involved in an activity

1 vaccine   

n.牛痘苗，疫苗；adj.牛痘的，疫苗的

参考例句：

• The polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。
• She takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。

2 conditional   

adj.条件的，带有条件的

参考例句：

• My agreement is conditional on your help.你肯帮助我才同意。
• There are two forms of most-favored-nation treatment:conditional and unconditional.最惠国待遇有两种形式:有条件的和无条件的。

3 vaccines   

疫苗，痘苗( vaccine的名词复数 )

参考例句：

• His team are at the forefront of scientific research into vaccines. 他的小组处于疫苗科研的最前沿。
• The vaccines were kept cool in refrigerators. 疫苗放在冰箱中冷藏。

4 advisory   

adj.劝告的，忠告的，顾问的，提供咨询

参考例句：

• I have worked in an advisory capacity with many hospitals.我曾在多家医院做过顾问工作。
• He was appointed to the advisory committee last month.他上个月获任命为顾问委员会委员。

5 warp   

vt.弄歪，使翘曲，使不正常，歪曲，使有偏见

参考例句：

• The damp wood began to warp.这块潮湿的木材有些翘曲了。
• A steel girder may warp in a fire.钢梁遇火会变弯。

6 vaccinations   

n.种痘，接种( vaccination的名词复数 )；牛痘疤

参考例句：

• Vaccinations ensure one against diseases. 接种疫苗可以预防疾病。 来自《简明英汉词典》
• I read some publicity about vaccinations while waiting my turn at the doctor's. 在医生那儿候诊时，我读了一些关于接种疫苗的宣传。 来自《简明英汉词典》