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Tuberculosis killed 1.4 million people last year. One reason TB is so deadly is that TB bacteria mutate quickly. But some scientists are hoping to get a step ahead of TB’s changes in the future by studying its past evolution.
Remnants of TB genes1 can remain in and infect person’s bones for centuries. A team of UK researchers has been able to isolate2 such TB sequences through an old skeleton using new rapid DNA3 sequencing. The proof of concept exercise was performed using the remains4 of a young woman buried in the 1800s. DNA sequencing showed that her strain matched one that circulated in the US a century ago. That match was based on tissue samples collected from a TB patient in upstate New York in 1905. The finding is on the Proceedings5 of the National Academy of Sciences.
Once older boned can be studied for this tale-tell genes, scientists might be able to get new insights into TB’s deadly moves and perhaps anticipate the/its next one.
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1 genes | |
n.基因( gene的名词复数 ) | |
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2 isolate | |
vt.使孤立,隔离 | |
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3 DNA | |
(缩)deoxyribonucleic acid 脱氧核糖核酸 | |
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4 remains | |
n.剩余物,残留物;遗体,遗迹 | |
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5 proceedings | |
n.进程,过程,议程;诉讼(程序);公报 | |
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